Synthesis of depsides and their biological activity

Abstract

Synthesized depsides were modified based on the core structure of jaboticabin, to enhance its biological activities. Desired depsides were synthesized through an esterification with methyl 2-(2- hydroxyphenyl) acetate (NT0) and a carboxylic acid compound. DCC and DMAP were required to activate the carboxylic group and solvent used was DCM. 2-(2-Methoxy-2-oxoethyl)phenyl 3- nitrobenzoate (NT1) and 2-(2-methoxy-2-oxoethyl)phenyl (E)-3-(2,6-dichlorophenyl)acrylate (NT18) showed powerful anti ɑ-glucosidase activity with an IC50 value of 68.7 μM and 84.8 μM. The IC50 values obtained from assay were lower than that of Acarbose, the standard reference (IC50 = 93.6 μM). On the other hand, none of the compounds showed good potential towards antioxidant activities.